(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) occlusion when administered at a dose of 0.128 mg/kg prior to occlusion or reperfusion.[5]

197508-62-6

C20H32O3

320.47

(±)14,15-EET;(±)14(15)-EET;(±)14,15-EpETrE

Ethanol:>50 mg/mL (per Rao Maddipati)
DMF:>50 mg/mL (per Rao Maddipati)
DMSO:>50 mg/mL (per Rao Maddipati)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years