Antitrypanosomal agent 7 (compound 18c) 是一种有效的抗锥体虫剂，具有良好的 ADME 特性。Antitrypanosomal agent 7 抗布氏锥虫(T. brucei) 的活性是 Nifurtimox 的两倍以上，IC50为 0.71 μM。Antitrypanosomal agent 7 与 DNA 有很强的相互作用，并能与富含 AT 碱基的 DNA 选择性结合。

Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is >2-fold more potent against Trypanosoma brucei ( T. brucei ) than Nifurtimox, with an IC 50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA [1].

2492436-38-9

C23H31Cl2N5O2

480.43

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years