Antitrypanosomal agent 6 (compound 18a) 是一种有效的抗锥体虫剂，具有良好的 ADME 特性。Antitrypanosomal agent 6 抗布氏锥虫(T. brucei) 的活性是 Nifurtimox 的两倍以上，IC50为 0.47 μM。Antitrypanosomal agent 6 与 DNA 有很强的相互作用，并能与富含 AT 碱基的 DNA 选择性结合。

Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is >2-fold more potent against Trypanosoma brucei ( T. brucei ) than Nifurtimox, with an IC 50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA [1].

C22H29Cl2N5O

450.4

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years