Sari 59-801 是具有口服活性的降血糖化合物，能够降低几个物种的血糖，且可以提高大鼠和小鼠的血浆中胰岛素水平。

Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release. SARI-59-801 was more potent in producing hypoglycemia (ED25 = 47 mg/kg) than their lean littermates (ED25 = 131 mg/kg).

The 2-hr hypoglycemic ED25 in fasting mice was 110 mg/kg; the plasma insulin levels were increased, with an ED50 of 47 mg/kg. The significant hypoglycemic activity was observed 2 hr after oral administration of 59-801 to fasting rats (ED25 = 86 mg/kg), while plasma insulin was elevated by 62% at 100 mg/kg.

80565-58-8

C18H23N3O2

313.39

Sari-59-801

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years