Glibornuride 是对 ATP 敏感的 K+通道 (KATP通道) 阻滞剂，pKi为 5.75。Glibornuride显示抗糖尿病活性。

Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.

Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) results in an enhance in body weights in the diabetic groups in Swiss albino rats. Administration of Glibornuride for 28 days, obviously enhances the liver lipid peroxidation levels in diabetic rats. Treatment with Glibornuride (28 days) reduces serum uric acid levels in diabetic rats [2].

26944-48-9

C18H26N2O4S

366.48

DMSO:250 mg/mL (682.17 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years