Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate. It has the antitumor activity.

Atrimustine (Bestrabucil) is a conjugate of chlorambucil and β-estradiol benzoate. Which has high affinity for tumor cells and enhances the antitumor activity of chlorambucil[1]. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by 3H-thymidine uptake assay[2]. The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line.

75219-46-4

C41H47Cl2NO6

720.72

KM2210;Bestrabucil;阿莫司汀

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years