Hexamethylene bisacetamide 抑制 BET Bromodomain 蛋白。

Hexamethylene bisacetamide inhibits BET Bromodomain Proteins.

As expected of a BET inhibitor, HMBA displaced BET proteins from chromatin, caused massive transcriptional changes, and triggered cell-cycle arrest and apoptosis in Myc-induced B-cell lymphoma cells.?Furthermore, HMBA exerted anticancer effects in vivo in mouse models of Myc-driven B-cell lymphoma[1].

3073-59-4

C10H20N2O2

200.282

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years