SBHA 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂，ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径，可研究甲状腺髓样癌。

SBHA (suberohydroxamic acid) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones.

In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively.

38937-66-5

C8H16N2O4

204.226

Suberohydroxamic acid;软木肟酸;SBHA

DMSO:49 mg/mL (239.93 mM),Need ultrasonic
H2O:8.16 mg/mL (40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years