1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 是一种阳离子脂质体的中性辅助脂质 (helper Lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

Each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent). With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effect on macrophages and DCs and Liposome-containing DOPE shows fusogenicity. LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.

4004-05-1

C41H78NO8P

744.03

DOPE;1,2-二油酰-SN-甘油-3-磷酰乙醇胺

DMSO:31.25 mg/mL (42.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years