TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-YAP 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。

TDI-011536 is a potent Lats kinase inhibitor. TDI-011536 interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

TDI-011536 (3 μM; 24 h) reduces Yap phosphorylation; TDI-011536 (3 μM; 5 days) induces proliferation of Müller glia in human retinal organoids[1].

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs[1]. TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes[1].

2687970-96-1

C19H16N4O2S

364.42

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years