| CAS NO: | 485-49-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 367.35 |
|---|---|
| Formula | C20H17NO6 |
| CAS No. | 485-49-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 21 mg/mL (57.2 mM) |
| Water:<1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: (R)-6-((S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-[1,3]dioxolo[4,5-e]isobenzofuran-8(6H)-one InChi Key: IYGYMKDQCDOMRE-ZWKOTPCHSA-N InChi Code: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 SMILES Code: O=C1O[C@@H]([C@H]2N(C)CCC3=CC4=C(OCO4)C=C23)C5=CC=C(OCO6)C6=C51 |
| Synonyms | d-Bicuculline; Bicculine; Bicucullin; BRN 0098786; NSC 32192; BRN0098786; NSC32192; BRN-0098786; NSC-32192 |
| In Vitro | In vitro activity: (+)-Bicuculline (1-100μM) dose-dependently inhibits the Cl- conductance generated by 40 μM GABA. (+)-Bicuculline also inhibits the agonist action of GABA at 40 μM at α1β2γ2L receptors. (+)-Bicuculline at 1 and 3 μM increases GABA EC50 values 1.6 times (41.0-67.0 μM) and 3.6 times (36.1-129.0 μM), respectively. Atα1β2γ2L GABAA receptors, (+)-bicuculline displays the general property of the competitive antagonist, producing a parallel shift of GABA concentration-effect curves and having no effect on the maximal response of GABA. In addition to being a potent GABAA receptor antagonist, (+)-bicuculine also blocks Ca2+-activated potassium channels. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Pflugers Arch. 1999 Aug;438(3):314-21; Eur J Pharmacol. 2003 Mar 7;464(1):1-8. |
m.cnreagent.com