RI(dl)-2 TFA 是一种有效的选择性 RAD51 介导的 D 环形成 (RAD51-mediated D-loop formation) 抑制剂，IC50为 11.1 μM，并抑制人细胞中的同源重组 (HR) 活性，IC50为 3.0 μM。

RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC 50 of 11.1 μM which also inhibits homologous recombination(HR) activity in human cells with IC50 of 3.0 μM[1].

RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA) [1]. When challenged with high salt concentrations, RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes[1].

1902146-75-1

C19H17N3

287.36

RI(dl)-2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years