SW-100 是一种选择性组蛋白去乙酰化酶 6 抑制剂，IC50为2.3 nM。它有提高的穿过血脑屏障的能力，相对于其他 HDAC 同工酶，还显示出对 HDAC6 的至少高 1000 倍的选择性。

SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.

SW-100 (0.01-10 μM; 48 hours) shows obvious enhance in the acetylated α-tubulin levels in a dose-dependent manner [1].

In mouse model of Fragile X syndrome, SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1].

2126744-35-0

C17H17ClN2O2

316.78

SW-100

DMSO:125 mg/mL (394.60 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years