L82 是一种选择性的、非竞争性的 DNA 连接酶 1 (DNA Lig1) 抑制剂 (hLig1IC50=12 μM)。L82 对乳腺癌细胞显示出抗增殖活性。

L82 is a selective and uncompetitive DNA ligase 1 ( DNA Lig1 ) inhibitor (hLig1 IC 50 =12 μM). L82 shows anti-proliferative activity to breast cancer cells [1] [2].

L82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells [2]. L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells [2]. Cell Proliferation Assay [2] Cell Line: MCF10A, MCF7, HCT116, and HeLa cells Concentration: 0-50 μM Incubation Time: 6 days Result: Reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa and HCT116, in a concentration-dependent manner. Cell Cycle Analysis [2] Cell Line: MCF7 cells Concentration: 50 μM Incubation Time: 0-48 hours Result: Showed a transient accumulation of cells at G2/M after 12 h, then showed an accumulation at G0/G1 that peaked after 24 h. Decreased in the S phase cell in accompany with the increase in the G0/G1 phase.

329227-30-7

C11H8ClN5O4

309.67

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years