IK1 inhibitor PA-6 是一种喷他脒类似物，是选择性的IK1(KIR2.x离子通道携带向内整流电流) 抑制剂，对人和老鼠中KIR2.x 电流的IC50值为 12-15 nM。它可上调 KIR2.1 的蛋白表达，诱导细胞内KIR2.1 的蛋白的积累。它在房颤和心律失常的研究中具有潜力。

IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents).

500715-03-7

C31H32N4O2

492.61

DMSO:120mg/ml (243.59 Mm),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years