DOTMA 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。

DOTMA is a tetra-methylated DOTA analogue. DOTMA is a cationic lipid and can be used as a non-viral vector for gene therapy. It has been used as a component in liposomes that can be used to encapsulate siRNA, microRNAs, and oligonucleotides and for gene transfection in vitro. It exhibits effective in vitro and in vivo gene transfection. DOTMA induces a positive charge on the liposomes and thus promotes efficient liposome- cell membrane interaction.

104872-42-6

C42H84ClNO2

670.58

N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium;Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride;DOTMA

DMSO:45mg/mL (67.1mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years