Tienilic Acid 是一种具有一定肝毒性的排尿酸利尿剂

Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity

In female and male Sprague-Dawley rats, Tienilic Acid decreased blood pressure and serum uric acid at 30 mg/kg. Tienilic acid decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg. Tienilic Acid significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly. Tienilic Acid also induced unicellular necrosis of small groups of liver cells[2].

40180-04-9

C13H8Cl2O4S

331.17

Tienilic Acid

DMSO:≥ 33.1 mg/mL
Acetone-d6:250 mg/mL (754.90 mM),Need ultrasonic and warming and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years