| CAS NO: | 64-65-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 155.19 |
|---|---|
| Formula | C8H13NO2 |
| CAS No. | 64-65-3 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 31 mg/mL (199.8 mM) |
| Water:<1 mg/mL | |
| Ethanol: 31 mg/mL (199.8 mM) | |
| Other info | Chemical Name: 2,6-Piperidinedione, 4-ethyl-4-methyl- InChi Key: ORRZGUBHBVWWOP-UHFFFAOYSA-N InChi Code: InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11) SMILES Code: O=C(CC(C)(CC)C1)NC1=O |
| Synonyms | Antibarbi; Agipnon; Ahypnon; Bemegrid; Eukraton; Malysol; Mikedimide; Zentraleptin |
| In Vitro | In vitro activity: Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. |
|---|---|
| In Vivo | Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression. |
| Animal model | Rats |
| Formulation & Dosage | Ora |
| References | Exp Physiol. 1990 Mar;75(2):199-209; Farmaco Sci. 1986 Jan;41(1):3-22. |
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