Compound 35 是埃博拉 (Mayinga) 和马尔堡 (安哥拉) 传染性病毒的优良抑制剂。

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses.

Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. Compounds 35 have shown good metabolic stability in plasma and liver microsomes (rat and human), and 32 did not inhibit CYP3A4 nor CYP2C9. These 4-(aminomethyl)benzamides are suitable for further optimization as inhibitors of filovirus entry, with potential to be developed as therapeutic agents for the treatment and control of Ebola virus infections.

T8686

C25H30F3N3O2

461.52

Compound 35

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years