BT18 是一种功能类似于胶质细胞源神经营养因子的分子模拟物。它能够影响 GDNF 家族受体 GFRα1 和 RET 受体酪氨酸激酶 RetA 的功能。

BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function.

BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines. BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines. BT18 (5-50 μM; 15 minutes) appears to phosphorylate RET in the concentration of 50 μM both in GFP-transfected and in GFRD1-transfected cells [1].

924811-53-0

C30H31F4N3O6S

637.64

BT18

DMSO:98 mg/mL (153.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years