Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的muscarinic-3 (M3)激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度，BHR是哮喘的重要特征。Methacholine bromide 可用于测量气道高反应性 (AhR)，作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助[2]。

Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR) which is a key feature of asthma. Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates [1] [2] [3] [4].

Methacholine bromide (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs [4]. Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited in a dose-dependent manner by bradykinin (4-40 μg/kg; i.v.) in mouse [5]. Animal Model: 9-week female BALB/c mice [6] Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: I.v Result: Induced severe bronchoconstriction.

333-31-3

C8H18BrNO2

240.141

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years