Pramlintide acetate(151126-32-8 free base) 是人胰岛淀粉样多肽的多肽类似物。它是一种抗糖尿病药物，在结直肠癌中具有抗肿瘤作用。

Pramlintide acetate is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.

Pramlintide inhibited the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s; 48.67 and 9.10 μg/mL, respectively;?p-value =0.013). Moreover, the addition of 5, 10, and 20 μg/mL of pramlintide to HCT-116 and HT-29 with 5-fluorouracil, oxaliplatin, or irinotecan induced the antiproliferative effect synergistically (R>1.6,?p-value<0.05).

187887-46-3

C173H271N51O55S2

4009

Pramlintide acetate(151126-32-8 free base)

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years