PH-002 是一种抑制载脂蛋白 E4 神经内分子相互作用的抑制剂(IC50:116 nM)。

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells (IC50: 116 nM in FRET)[1].

PH-002 (100 nM) enhances dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons). PH-002 is also shown to enhance COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus. COX1 levels are increased by ~60% after 4 days of treatment with PH-002 (200 nM) [2].

1311174-68-1

C27H33N5O4

491.58

PH-002

DMSO:75 mg/mL (152.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years