Posovolone (Co 134444) is an orally active sedative-hypnotic neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.

In mice, Co 134444 (0.5-10 mg/kg, IP, 15 min; 1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED 50 of 3.3 mg/kg after IP administration and 9.8 mg/kg orally. Similarly, protection against maximal electroshock (MES) is observed with an ED 50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED 50 of 23.6 mg/kg and 25.3 mg/kg, respectively[1].

256955-84-7

C26H40N2O3

428.61

Co 134444;Posovolone

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years