Zamifenacin fumarate 是肠道选择性毒蕈碱M3受体的有效拮抗剂， 可显著降低肠易激综合症的结肠蠕动。

Zamifenacin fumarate is a potent and gut-selective antagonist of muscarinic M3 receptor.

Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].

127308-98-9

C31H33NO7

531.6

扎非那星富马酸盐;UK-76654 fumarate;Zamifenacin fumarate

H2O:1 mg/mL (1.88 mM),Need ultrasonic and warming and heat to 60°C
DMSO:55 mg/ml (103.46 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years