Carebastine 是 Ebastine 的活性代谢产物，可抑制巨噬细胞移动抑制因子的表达。它是组胺 H1 受体拮抗剂，可抑制 VEGF 诱导的 HUVEC 和 HPAEC 增殖，迁移和血管生成。

Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.

Carebastine inhibits VEGF-induced HPAEC and HUVEC proliferation, migration, and angiogenesis in a dose-dependent manner [1]. Carebastine suppresses the expression of macrophage migration inhibitory factor [2].

90729-42-3

C32H37NO4

499.64

Carebastine

DMF:24 mg/mL (48.03 mM),Need ultrasonic and warming
DMSO:1 mg/mL (2.00 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years