Cyclizine dihydrochloride是一种哌嗪衍生物，是选择性组胺H1受体拮抗剂，可用于恶心、呕吐和头晕的研究。

Cyclizine Dihydrochloride is a histamine H1 antagonist. It is given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness.

在健康成人志愿者体内,Cyclizine（50 mg,p.o.）给药2 h后,可达血药峰浓度约70 ng/mL,血浆消除半衰期约为20 h.Cyclizine（p.o.）30 min内可产生效果,1-2 h内达到最大作用效果,可持续4-6 h.与二苯甲基哌嗪相比,Cyclizine的抗组胺活性几乎可以忽略.

Cyclizine可使食道下端括约肌张力增加,使曲折器官的灵敏度降低。Cyclizine可抑制中脑的的催吐中心。

5897-18-7

C18H24Cl2N2

339.3

Cyclizine 2HCl;Marzine hydrochloride;赛克利嗪二盐酸;Cyclizine dihydrochloride

Ethanol:<1 mgml
H2O:62 mg/mL (182.7 mM)
DMSO:7 mg/mL (20.63 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years