LR-90 是一种晚期糖基化终产物抑制剂，能够抑制人单核细胞的炎症反应，也可用于研究糖尿病动物模型。

LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.

LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours[1].?LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells[1].LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours[1].

LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation[2].LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats[2].

245075-84-7

C35H34Cl2N4O8

709.57

LR-90

DMSO:95 mg/mL (133.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years