ACT-389949 是一种高效的甲酰肽受体 2/脂蛋白 A4 受体(FPR2)/(ALX)选择性激动剂，对 FPR2/ALX 进行内化入单核细胞的EC50值为 3 nM。它对炎性疾病具有潜在的研究价值。

ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. It has the potential for the treatment of inflammatory disorders.

ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours. Administration of ACT-389949 causes a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes [1].

1258417-54-7

C20H18F2N6O3

428.39

ACT-389949

DMSO:10 mg/mL (23.34 mM),ultrasonic and adjust pH to 1 with HCl
Powder: -20°C for 3 years
In solvent: -80°C for 2 years