PIKfyve-IN-1 是一种高效且具有细胞活性的化学探针，可抑制 3 磷酸磷脂酰肌醇 5-激酶 (PIKfyve)，IC50值为 6.9 nM。PIKfyve-IN-1 可用于病毒学中 PIKfyve 的研究。

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology [1].

PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC 50 values of 6.9 nM and 4.01 nM, respectively [1]. PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry [1]. PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC 50 values of 23.5 nM and 19.5 nM, respectively [1]. PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis [1]. Immunofluorescence [1] Cell Line: Calu-3 cells Concentration: 1 μM Incubation Time: 1 h Result: Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.

C20H21N5

331.41

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years