SR-16435 是NOP/μ-opioid受体部分激动剂，具有较高的结合亲和力 (NOP 受体Ki=7.49; μ-opioid 受体Ki=2.70)。SR-16435 具有缓解疼痛的作用。

SR-16435 is a nociceptin/orphanin FQ ( NOP )/ μ-opioid receptor partial agonist, with high binding affinity (NOP receptor K i =7.49; μ-Opioid receptor K i =2.70). SR-16435 can relieve pain [1].

SR 16435 (10, 30 mg/kg; s.c.; single-dose) produces dose-dependent increase in tail-flick latency and induces antinociception [1]. SR 16435 (10, 30 mg/kg; s.c. once daily for 9 days) produces an increase in tail-lick latency across days, induces conditioned place preference, and decreases global activity [1]. Animal Model: 20 to 25 g male ICR mice [1] Dosage: 10, 30 mg/kg Administration: s.c. for single-dose Result: Produced dose-dependent increase in tail-flick latency and induced antinociception. Animal Model: 20 to 25 g male ICR mice [1] Dosage: 10, 30 mg/kg Administration: s.c. once daily for 9 days Result: Produced an increase in tail-lick latency across days, induced conditioned place preference, and decreased global activity.

857262-16-9

C22H30N2O

338.49

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years