ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells (EC50 = 55 nM).

1355327-02-4

C29H30ClFN4O2

521.03

ML-309 (hydrochloride)

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years