Kemantane 是一种免疫激活剂，是 Adamantane 衍生物。

Idramantone is an immune agonist.

Assays with human placental aromatase: Microsomes are prepared from human placenta and stored at -80℃. The rate of aromatization is determined by measuring the tritiated water released from [1β-3H]A. The assay is carried out in a final volume of 1 mL, in 10 mM phosphate buffer, pH 7.5, containing 100 mM KCl, 1 mM EDTA, 1 mM dithiothreitol, 100 μM NADPH, the enzyme preparation and the appropriate concentrations of Exemestane (in duplicate) and the substrate. After a 10 min incubation at 37 ℃, the assay is terminated by the addition of 4 mL cold chloroform. The acqueous phase is treated with a charcoal suspension, the supernatant is removed and counted for radioactivity by liquid scintillation in Rialuma. For the determination of the IC50 values, various concentrations of Exemestane are incubated with 20 μg of microsomal protein, in the presence of a fixed amount (50 nM) of [3H]A.

20098-14-0

C10H14O2

166.22

Kemantane;伊屈孟酮 (INN);伊决孟酮;5-Hydroxy-2-adamantanone;Idramantone

H2O:30 mg/mL (180.5 mM)
DMSO:31 mg/mL (186.5 mM)
Ethanol:31 mg/mL (186.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years