3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.[3],[4] In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin.

1331891-93-0

C13H15F3N2O6S

384.33

APAP-Cys;3-Cysteinylacetaminophen (trifluoroacetate salt);3-(cysteine-S-yl)acetaminophen;3-Cysteinylacetaminophen (trifluoroacetate salt)

DMSO:0.17 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years