Bromfenac Sodium Sesquihydrate 是一种可口服的COX抑制剂，抑制COX-1和COX-2的IC50值分别为 5.56 和 7.45 nM。它是一种溴化非甾体类抗炎药，有用于白内障的术后炎症和疼痛以及假晶状体囊状黄斑水肿的研究。

Bromfenac Sodium Sesquihydrate is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic administration, bromfenac binds to and inhibits the activity of cyclooxygenase II (COX II), an enzyme which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins (PG). By inhibiting PG formation, bromfenac is able to inhibit PG-induced inflammation, thereby preventing vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, an increase in vascular permeability and an increase in intraocular pressure (IOP).

120638-55-3

C30H28Br2N2Na2O9

766.347

Bromfenac monosodium salt sesquihydrate;溴芬酸钠;Bromfenac sodium;Bromfenac sodium hydrate

DMSO:35 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years