Alagebrium chloride 是晚期糖基化终产物 (AGE) 抑制剂。

Alagebrium Chloride is an advanced glycation end product (AGE) inhibitor, and has proven effective in reducing systolic blood pressure and providing therapeutic benefit for patients with diastolic

Alagebrium treatment in diabetic rats significantly inhibits neointimal hyperplasia after carotid balloon injury due to its inhibition of intracellular ROS synthesis, which results in inhibition of RASMCs proliferation[1].

Rat aortic vascular smooth muscle cells (RASMCs) were treated with 1-100 μM of alagebrium added 24 hours before the addition of AGEs.?This in vivo study was done using 8-week-old male rats that were injected intraperitoneally with 80 mg/kg STZ.?Sixteen weeks later, the diabetic rats were treated with 10 mg/kg alagebrium for 4 weeks, after which carotid artery balloon injury was induced.?After 4 weeks, the animals were sacrificed for histological analysis[1].

341028-37-3

C13H14ClNOS

267.77

阿拉氯胺;4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物;ALT711;Alagebrium chloride

DMSO:25 mg/mL (93.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years