Exo1 是一种胞吐途径的化学抑制剂。

Exo1 is an inhibitor of the exocytic pathway

Exo1 is a modifier of Golgi ARF1 GTPase activity. It provides an independent means to interfere with Golgi activity, because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects). Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I[1] .

75541-83-2

C15H12FNO3

273.26

Exo1

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years