| CAS NO: | 13463-41-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| 10g | 电议 |
| 50g | 电议 |
| 100g | 电议 |
| Molecular Weight (MW) | 317.7 |
|---|---|
| Formula | C10H8N2O2S2Zn |
| CAS No. | 13463-41-7 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 30 mg/mL (94.4 mM) |
| Water:<1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Solubility (In vivo) | Chemical Name: (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc InChi Key: YZYHTCSREWDSOL-UHFFFAOYSA-O InChi Code: InChI=1S/C5H6NOS.C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h1-5,8H;1-4H;/q2*-1;+1/p+1 SMILES Code: C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1 |
| Synonyms | OM-1563; AI3 62421; OM 1563; BC J; AI3-62421; BCJ, AI362421; BC-J OM1563; Biocut ZP, Finecide ZPT, Pyrithione zinc; Zinc pyrithione |
| In Vitro | In vitro activity: Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential. |
|---|---|
| In Vivo | Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. |
| Animal model | |
| Formulation & Dosage | |
| References | Appl Environ Microbiol. 1995 Sep;61(9):3385-90; Environ Toxicol Chem. 2010 Nov;29(11):2583-92. |
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