Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50s = 10 and 7 μM, respectively). Ricinelaidic acid (1 mg/kg, i.v.) inhibits bronchoconstriction induced by LTB4 in rats by 46%.

540-12-5

C18H34O3

298.467

Ricinelaidic Acid

DMSO:2 mg/mL
PBS (pH 7.2):2 mg/mL
Ethanol:Miscible
DMF:3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years