Verlukast is an (R)-enantiomer of MK-571 and a potent and selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig (IC50 = 3.1 +/- 0.5 nM) and human (IC50 = 8.0 +/- 3.0 nM) lung homogenates and dimethyl sulfoxide differentiated U937 cell membrane preparations (IC50 = 10.7 +/- 1.6 nM) but is essentially inactive versus [3H]leukotriene C4 binding in guinea-pig lung homogenates (IC50: 19 and 33 microM).

120443-16-5

C26H27ClN2O3S2

515.09

MK 679;MK-679;L 668019;L-668,019;MK 0679;L 668,019;Verlukast

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years