A68930 hydrochloride 是一种多巴胺D1受体激动剂，可用于支气管扩张的研究。

A68930 hydrochloride is a dopamine D1 receptor agonist which can be used for the research of bronchiectasis [1].

The dopamine D1 receptor protein was detected in native human airway epithelium and three sources of cultured human airway epithelial cells. A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein [1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression [1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels [1]. Western Blot Analysis [1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.

130465-39-3

C16H18ClNO3

307.77

A 68930 hydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years