Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50< 5.5).

235082-52-7

C60H90N20O11S

1299.56

MEN 11270

30% acetonitrile / water:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years