13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound. It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively. 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 value of 40 nM. Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.

19313-28-1

C20H36O5

356.5

13,14-dihydro Prostaglandin E1;13,14-dihydro Prostaglandin E1

PBS (pH 7.2):>1.6 mg/mL (from PGE1)
Ethanol:>50 mg/mL (from PGE1)
DMF:>100 mg/mL (from PGE1)
DMSO:>50 mg/mL (from PGE1)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years