10β,17β-dihydroxyestra-1,4-dien-3-one is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol. It alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes.

549-02-0

C18H24O3

288.38

DHED;10β,17β-dihydroxyestra-1,4-dien-3-one

DMSO:250 mg/mL (866.91 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years