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FKGK 18
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FKGK 18图片
CAS NO:1071001-09-6
包装:50 mg
市场价:9397元

产品介绍

产品描述

FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits glucose-induced increases in prostaglandin E2 production and insulin secretion in human pancreatic islets when used at a concentration of 10 μM and inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2β in a concentration-dependent manner. FKGK 18 (20 mg/kg, 3 times per week) reduces blood glucose levels in an intraperitoneal glucose tolerance test, decreases the incidence of diabetes, and increases serum insulin levels in non-obese diabetic (NOD) mice.

Cas No.

1071001-09-6

分子式

C16H15F3O

分子量

280.28

别名

FKGK 18

储存和溶解度

DMSO:20 mg/mL
DMF:20 mg/mL
PBS (pH 7.2):2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years