Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

1638644-62-8

C16H15ClN4O2

330.77

OD 36 hydrochloride;OD36

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years