cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.

cGAMP directly activates murine and human dendritic cells in vitro. cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice [2]. On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding IL-1, IL-6, or TNF [3]. cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs [4].

cGAMP stimulates the antigen-specific cytokine production by spleen cells of immunized mice [2].

849214-04-6

C20H24N10O13P2

674.41

3',3'-cGAMP;Cyclic GMP-AMP;cGAMP

H2O:20 mg/mL (29.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years