RSV/IAV-IN-3 (compound 14'i) 是呼吸道合胞病毒 (RSV) 和甲型流感病毒 (IAV) 的双重抑制剂，EC50值分别为 2.92 μM 和 1.90 μM。RSV/IAV-IN-3 对 H1N1 和 H3N2 具有抗病毒作用，在 MDCK 细胞中的 EC50值分别为 3.25 μM 和 1.50 μM。RSV/IAV-IN-3 以剂量依赖性方式显着抑制荧光素酶的活性，EC50值为 3.89 μM。RSV/IAV-IN-3 抑制 IAV 感染和 RdRp 活性。RSV/IAV-IN-3 在进入后阶段抑制 IAV 和 RSV 复制。

RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza A virus (IAV) with EC 50 values of 2.92 μM and 1.90 μM,respectively. RSV/IAV-IN-3 has antiviral effect against H1N1 and H3N2 with EC 50 values of 3.25 μM and 1.50 μM in MDCK cells, respectively. RSV/IAV-IN-3 significantly inhibits the activity of luciferase in a dose-dependent manner, with an EC 50 of 3.89 μM. RSV/IAV-IN-3 inhibits IAV infectivity and RdRp activity. RSV/IAV-IN-3 inhibits IAV and RSV replication at the post-entry stage [1].

2395007-81-3

C19H19BrN2O3S

435.33

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years