GATA4-NKX2-5-IN-1 剂量依赖性地抑制GATA4–NKX2-5转录协同作用(IC50:3 μM)，但不影响参与调节 GATA4 磷酸化的蛋白激酶的活性。它能够调节肥大激动剂诱导的心脏基因表达。

GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.GATA4-NKX2-5-IN-1 dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC50 of 3 μM.

544681-96-1

C21H23N3O2

349.43

GATA4-NKX2-5-IN-1

DMSO:65 mg/ml (186.02 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years