Thalidomide-4-OH 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used to recruit of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) is a linker to form PROTACs

Thalidomide-OH has weak anti-angiogenic activity. Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].

5054-59-1

C13H10N2O5

274.232

Cereblon ligand 2;E3 ligase Ligand 2;Thalidomide-4-OH

DMSO:30 mg/mL (109.40 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years